Updated on May 6, 2020
HairClone Timeline Update May 2020
Today, HairClone sent out its latest newsletter and first official update of 2020.
Newsletter May 2020
Here are the important bullet points from HairClone’s latest newsletter including an invitation to complete a survey for the company:
Business News
- In Oct 2019, we were successful in winning a significant 15 month grant from the UK Government to develop our cell based treatment and we began work on this on January 1st.
- We congratulated Susan Limbu, our lab associate, who left to start her PhD in Ralph Paus’ lab and welcomed Dr. Jennifer Dillon who joined us as a Senior Scientist last November.
- As most of the inhabitants of the planet are in some form of social restriction, we would like to invite you to take some time to tell us about your experience of hair loss and what you would be looking for in a treatment.Please follow the link if you are interested in taking part in our survey:https://www.surveymonkey.co.
uk/r/FSTZCNF
Follicle Banking
- The Farjo Clinic launched our follicle banking service at the end of last year. The service has proved popular with both hair transplant patients and clients who solely want to bank their follicles.
- Our clinical partners overseas (US & elsewhere)对卵泡银行和ha有接受培训2022世界杯附加赛预测ve been audited by the tissue bank. They are keen to start providing the banking service as soon as lockdowns permit.
- Follicle banking is priced at US $2,000. This includes cryopreservation, the first year’s storage and taxes. There will be an annual charge of US $150 to maintain the follicles in the bank. All profits from banking will go to development, authorisation and licensing of the treatment system. Clinical Partners will set their own charges for extraction.
The photo below depicts some of the latest research from HairClone. In each of the pink droplets sits dissected hair follicle bulbs preparing to be cultured over a period of days.
Timeline Update
Since today’s newsletter did not specifically address any potential delays on HairClone’s progress I’ve asked CEO Paul Kemp to provided some commentary on a projected timeline for HairClone’s cell expansion service and how the coronavirus situation has affected their timeline. (I had a feeling that some readers might be curious about that ?) :
“Our timeline has definitely been affected by Covid-19. The clinics, lab and GMP facility all closed at the end of March When the lockdown here started. We don’t know yet when all these will reopen and we need them all to open in order to continue, but are imagining the end of May at the earliest. Innovate UK have agreed to extend our grant by 3 months and that is probably a good estimate of the delay though we can’t tell yet whether a second wave will close things again so there are a lot of unknowns at the moment.”
HairClone’s previous aim for opening their cell expansion service was Q1 2021, thus, we can estimate that the treatment could be available by summer 2021 if all goes well from here.
All in all, the projected timeline is good news and possibly quite better than expected. Let’s hope things reopen for good this year in HairClone and all good businesses worldwide.
We need a company which could usually tell us their situation like HairClone. That makes me feel hpoe. Thanks admin and Pau Kemp.
I’m a chinese student and I’m going to London for a master degree in Semptember, about 2 years. And I wonder if it’s possible that i chould get HairClone treatment during my study time?
This company seems to be pretty confident about their treatment…
I just looked in the timetable again) you estimate 2021 uk specials… What does it mean? Only very few people for enormous price? Or do you mean the people who are using the banking service? It would be really interesting to know what the treatment will costs…
Hi Stephan, if you check out previous HairClone articles it will describe the Specials. It means doctors can offer the treatment unnarketed.
Let’s not forget that HairClone freezes follicles; it isn’t a prospective outfit a la Tsuji and J. Hewitt. Have a scintilla of hope if you desire, but don’t count your chicks until they hatch!
None of their survey questions or research have addressed whether scalps that have undergone transplantation would be suitable for treatment.
Scottie, I imagine that they may want to test this on hair transplant patients to find out, and I’m sure they will have a chance through former patients at the Farjo office! I’ll see if Paul can comment on this at all.
Can anyone please tell me how this HairClone treatment works ?
Much appreciated if anyone does.kha
So when will it come out I’m 17 and a Norwood 4 and I want to end myself . Paul please help
Hi Scottie
Great question and its this kind of thing we need as it is difficult to imagine every patients situation. It is obviously patient dependant and the treatment we are working to develop is aimed at rebuilding actively miniaturising hair follicles but a previous transplant shouldn’t prevent that assuming a) there are still suitable hair follicles that could be harvested and b) there are still follicles that are actively miniaturising
regards
Paul
This will be a treatment which we find out if it works before many of the others. Even before samumed, follicum etc. They will be able to produce the patient results for all to see, I hope which are good.
This will prob grow just sparse hair. Fillers in between fue gaps. At least what I believe. Not sure this will grow 200 hairs cm2?
No, I don’t think this treatment is slated to grow 200 per cm2. I don’t know of any treatment that should be able to do that really. HairClone is aiming this as a thickener/rejuvenator for thinning hair areas.
Nice, thank you Paul
I do not appreciate any treatment if it takes hair from my donor area in every 2-3 years only for maintenance (for that we have finasteraide already). To be real, I’m more hyped on samumed and breezula
With the follicle banking service, the follicles are only extracted once.
Thanks Sam.
Samumed, really?
But anyways, the proposed HairClone treatment does not take donor hair every 3 years. They take 50 or so follicles one time and then freeze them and call upon the follicles every few years to make the DP cell therapy for you.
Well irrespective of alot of the Hairclone naysayers here, I for one am putting some eggs in this basket.
I have already banked and am in the queue for when they’re ready to treat patients.
I personally believe replenishing and replacing DP cells within the Dermal Papilla with healthy non-dht susceptible DP cells is going to one of the most effective ways of treating hairloss.
I just really hope they can get back to work as soon as possible.
Hello !
I am very interested in this treatment.
I would be glad to be one of the first person outside UK to be treated.
Living in France , let me know if we may have an arrangement.
Hope you will be successful
JC
Thanks Matt – how much did you pay for banking.
Farjo site says £2.5k but the Hairclone newsletter says $2k usd.
The Farjo site says the actual injections will cost the same as a medium hair transplant each time!?! so £8k to get some injections?
https://www.farjo.com/news/hairclone-is-the-concept-the-future-of-hair-restoration/
This is encouraging news, though I don’t think it is for me: I am a little too far gone and am really waiting for full hair cloning/ multiplication. I had a consultation a year back and the talk then was of around £7000 per treatment. As one would need several applications I think we are probably looking at between £20,000 and £30,000, but no doubt this will be clarified in time. As I say, I think I will wait for full hair cloning, but if I had more hair I would seriously consider this. I wish HairClone every success and hope they move to full cloning ASAP. That will be the real game changer.
In reply to Matt and Alan
Thanks Matt, we hope to be back up and running soon too and in the interim are catching up drafting the large number of documents needed for GMP manufacture.
And to Alan’s comment rebuilding and repairing a patient’s own follicles is our first aim and in some patients with a mix of actively miniaturising follicles and follicles that are beyond the state that they can be rebuilt then a mix of cell therapy and hair transplantation may be of help. For some patients however you are right and creating brand new hair follicles will be the only option. As you mention it will be expensive, at least initially, as probably two cell types will need to be grown independently then brought together in 3D and cultured for some period of time to produce a hair rudiment which will then need to be implanted one at a time and then allowed to produce a hair shaft of the correct thickness and direction etc.
These are all achievable hurdles but it will take time and a lot of investment
Regards
Paul
Hi Paul,
I think what you are talking about is exactly what Tsuji is doing since 2016. If I am right, the Japanese are developing also the same DP-Cell-Therapy you are doing, and furthermore an iPSC-approach.
Are you also planning to develop a „de novo“-technology?
Given Tsuji‘s know-how, funding, partners, legal advantage I think the Japanese might be years ahead.
Thanks for all your work!
B.
HairClone has mentioned a few times that they aim to develop a de novo hair technology at some point down the line, most likely a few years out.
一个点I’d make is, if Tsuji was years ahead he’d likely have a therapy on market or at least in a trial by now…
Hi Admin, thanks for your answer. I didn’t know that Paul is also considering a „de novo“ therapy, that’s great. I believe in Hairclone, Paul proofed with Intercytex many years ago that this works!
Regarding Tsuji‘s trial: it is widely said that they finished trials in 2019. I have no written proof for that though. Regarding „de novo“-therapy, it is highly likely he is years ahead: Rapunzel, Stemson, Hairclone, Stemicure – there’s not even a release year announced. Tsuji still says 2020!
DP-cells they are seemingly on the same timeframe as Hairclone.
Thanks for being part of the discussion, Ben. My guess is that the talk of Tsuji finishing trials in 2019 are due to miscommunication. It would be fantastic news if Organ Technologies/Dr. Tsuji enter human trials for any kind of hair therapy by Q2 2021.
As for your statement „implanted one at a time“, OrganTech developed a fully automated proprietary device to do this, minimally invasive. Found the patent somewhere online years ago, can‘t find it anymore.
Thank you for all of your work. If I am understanding this correctly, as a Norwood VI, this treatment would not be an option for me? How far is too far gone to rejuvenate a hair follicle? Is diffuse thinning to large of an area to treat? Thanks.
Hi Paul,
I am following your comments and i would like to know why your company is not going public to raise fund.
I will personally buy your company shares, because my wife needs hair cloning.
Best of luck
David
Admin, do have any news about Stemore’s “functional cosmetic” as they’re supposed to release it this year?
Hey The, no news from Stemore at the moment, but i hope theyre staying productive during this time. Hopefully by summer I will have some updated info to share from them, thanks for the interest.
Hi Dr Kemp
Thanks for answering our questions. Do you currently know if your treatment will last 2 to 3 years based on your experience? I ask this because with Shiseido, although not the same treatment as yours, their treatment only lasted about 9 months. Thanks
Thanks for your question and I wish we knew the answer to it. Our intention is to replace the DHT inhibited DP cells that are lost during androgenic alopecia with DP cells that are not DHT inhibited. Our hope is that that converts these follicles to behave like the ones on the side of the head which don’t miniaturise. Ongoing treatments would then convert newly miniaturising follicles as the “wave” of hair loss progressed. Part of the grant funding is to develop ways to test this, but at the moment we have no data to support it.
how does shiseido compare to hairclone?
Is paul kemp able to comment on other treatments such as samumed, breezula and follicum or any cosmetic topicals like guiliani?
I’m not sure if he follows the topicals very closely but I’m sure he’s able to comment on them if he feels like it.
Hi
Thanks for your email. I don’t think it is fair for one company to comment on the products of another as, apart from anything, I would not be impartial.
All I can say about Shiseido, is that they are using dermal sheath cells and we are using dermal papilla cells.
I am sorry that I can’t provide more information
Regards
Paul
Hi Paul,
I am 40 years old and would like to bank my hair and be ready once the treatment is available I am living out side UK but I can come any time of course after Covid-19 is over
Kindly let me know and I will travel strait away
如果我大胆的头皮部分仍被minihair覆盖s, does this mean the treatment would work? Are those by eye visible minihairs able to regenerate by this treatnent?would be really nice to see some photo evidence of the improved treatment when available, since the only related photos i have seen are from 2012( in the original article on FT)
We do know from work published by ARI that hair can miniaturise beyond the point they can be recovered but at the moment we don’t know details about what that limit is. Clinicians will hopefully be able to generate this data when we start providing cells to them next year, coronavirus willing
Do you guys have any idea concerning this. it appears to be some new product for alopecia areata but I couldn’t find much about it.
http://hairlosscure100.blog.fc2.com/blog-entry-318.html?sp
It’s a JAK inhibitor, there are several in clinical trials now for alopecia areata.
Admin can you please tell how this hair cloning treatment works ?
It would be of a lot of help please.
It’s very similar to Replicel, please see Replicel’s video on youtube, except it uses dermal papillae cells instead of dermal sheath cells.
Hi Kris
Firstly, it’s important to say that we don’t have this treatment yet so we dont know how it works, or even if it works. Please see my answer to Sam’s question about regarding our intended mode of action for the treatment. There is a lot of previous data from scientific and clinical groups to support this concept but as yet we don’t have definitive data yet and won’t until clinicians start to use these cells next year.
regards
Paul
Thank you Mr Paul Kemp much appriciated and all the best for your work.
Ain’t this just a simple hair freezing for later use?!
No, please review HairClone articles and comments on this site for explanation of therapy.
Paul Kemp
For a diffuse diluent like my case, do you think this treatment will be adequate?
Thanks
Thank you very much Paul for taking our questions siriousky and answering! It seem like FT estimation with 2021 is very optimistic after what was said)
Why do you say that Stephan?
Hi FT. I would really appreciate the treatment to be out in 2021 and have the feeling it would be effektive for me) but if the CEO sais they still don’t know very important details(the regenerable follicle state) and if it actually worked or not… one yeae from now seems very unrealistic… Espesially if you take corona into account…
Sorry, but just compare it to shiseidos progress. Even if Hairclone would be ready in 2023 the would be very fast
Ok, Stephan, but CEO Kemp has stated right here in these comments that he plans to “begin providing the expanded cells next year (2021), coronavirus willing”
Maybe you have not heard of the system which is being done in the UK. The cells will be available for doctors to use and treat patients with before the clinical trial process begins. There are many articles here on FT which describe the regulations around this.
Thank you a lot for replying even though i am not prepared for discussion. Should read everything carefully before argueing)
So it really seems we could get a shiseido likeor perhaps better treatment in 2021, even in europe) the only thing now wasnt clear through all articles. If you attend the treatment at one of the partner- clinicians… Will it be at your own risk? Or is the clinician responsible?( A bit worried of safety issues) Another question to Paul… Will you be the first to receive this treatment? Will it be possible to see new result evidence before the long trial way?
感谢你的阅读在斯蒂芬的事情。一个点I’d make is DP cell therapies have been through 2 trials with intercytex, and at least 2 trials with Aderans and no major adverse events were seen. Can’t predict the future but all in all DP cell therapies are thought to be very safe. More than likely you’d have to sign some sort of agreement similar to traditional hair transplant patient agreements.
I’m a little concerned about this working for females. With female AGA there is thinning and miniaturization happening all over the head, not just in the areas of MPB. Would they even attempt this in females?
I’m sure they will attempt this for females but I can’t remember HairClone’s stance about finding follicles which are DHT resitant in females. Maybe he will chime in again about that hopefully.
Two questions for Paul Kemp:
1) Personally, I have never been impressed with the results I’ve seen from patients who had had PRP or Regenera Activa. When I see the before and after pictures, I don’t see much difference. I know you don’t even know if your treatment will be successful yet, but I’m assuming the aim is to make a noticeable cosmetic difference? Simply put, are you aiming to provide a treatment that will offer better, more noticeable cosmetic results than PRP?
2) If someone has miniturised hair on the side or back, does that mean the treatment will be pointless?
Thanks in advance, Paul! Appreciate you taking the time to answer our questions.
Completely off topic but would love some insight from everyone – How did Elon Musk maintain such a successful hair transplant?
I’ve been debating getting one for years now, but worried I will continue to loose my hair and then I’ll have hair just in the front of my head and the back, leaving an odd bald spot in the middle.
Finasteride…very effective on the back of one’s head, even someone with a head as big as Elon’s!
Haha nice one. Yeah I’ve been using Fin for about 2 years now. It’s not stopping my hair loss but it has definitely slowed it down some. Thanks for the input Yoda.
嗯,即使你的头?尤达的头发has remained thick in the back 2/3 of my head, started to loose ground in the front after 20 years on fin. I made the switch to Dut about three years ago which helped. However, as the admin knows I’m on a fairly aggressive regime that evolves with time and alternative options…or variants of the big three. Good luck Stef, and remember that Yoda is not a medical doctor, just a guy that’s been in the game longer than some of FT’s readers have been alive!
Elon did have great results, that’s for sure. As long as it’s still his growing hair its a 10/10 result.
Oh interesting. You think there is a chance that’s not just a hair transplant? Plugs?
I never speculated myself, as I don’t like to do that about other people’s hair, and then somewhere on the internet I heard someone claim that it was a hair system. I thought, hmm, that’s possible.
Dr.Paul,
Can you give us an idea as to how big of an area you can treat in one session with this new cell based tratment? Is it just one injection per session or multiples?
And how much of an area does one injection cover?
Hairclone shiseido and all things dp multiplication related have failed to produce n5 to n0 power. Hairclone is MULTIDP tech so not optimistic. Tsuji and stemson are the only treatments capable of n5 to n0. There’s not much point in even paying attention to treatments if your n5 like Rogan or someone.
It’s true NW5 – NW0 will take a follicle cloning approach. TissUse could be considered in this category as well for now.
I genuinely wanted to ask a question FT.
Since you’re created this website were there any treatments in the pipeline then in 2015 like today which were supposed to come around soon ?
If there were do you know now what happened to those treatment ?
Can you please fill me up on this one
There have only been 2 clinical treatments which come to mind that were in the pipeline around 2015-16 that are not in it now, there have been more additions, though.
Bimatoprost头皮被艾尔建的考题but they decided to drop the program. Perhaps results were around equal or slightly less to minoxidil and they thought it wouldn’t be worth it. Setipiprant was also trialed by Allergan but did not produce a significant hair growth increase and that program was dropped as well. Other therapies like Replicel and Hisotgen were supposed to be released around 2018-2019 but both have experienced delays.
Thank you Admin
Do you believe the treatments which are now in pipeline are more promising than those around 2015-16 ?
I believe treatments like Breezula and Triple Hair ones were quite promising.
What, if anything, is in the pipeline where they would take ~50 hairs from the back of my head, clone them into a thousand hairs and put them in the front of my head? Thanks
Organ Technologies, TissUse, Rapunzel
What makes tissuse a potentially better solution?
Better than what? I believe TissUse has some sort of proprietary process for culturing their DP cells which seems to maintain the majority of gene expression.
What is with Stemson?
Yes, Stemson is as well but they may not even require hair follicle samples. They have talked about it creating new follicles with only a sample of blood to create iPS cells.
Just a small example of how opinions differ across the internet. I was just talking to Fuji from the Japan Hair Loss Cure blog and he thinks Organ Tech/Dr. Tsuji treatment could take up to 10 years to be out. Doesn’t mean he’s right, but it’s an opinion.
I think Fuji is closer to being right than those that were expecting to hop on a plane to Japan this year or next and come back with a full head of hair. Literally thinking Organ Tech was going to go from 0 to 100 mph in less than a second. I feel bad for the guys who fell into this trap, especially if it kept them from seeking out the treatments that are readily available today. Nothing to loose but time and hair.
Yes, I’ve agreed the concept that Tsuji’s treatment was going to be ready to go with consistent results and streamlined by the end of 2020/21 was a bit grandiose. I am hopeful though, that it will come before the end of this decade. 2025 would be a dream come true for millions of men and women.
This seems a long time when we know that Tsuji announced in 2019 (press articles) that it would be able to market the product in 2020-2021
嗨,只是一个小问题。他们会移植啊n our head follicles or grown hairs ? Because transplanting grown hairs is soso and don’t give natural look ect… Plus it’s not intended on long hairs. I hope its just follicles and then they grow in a natural manner.
Jonathan, did you mean this question for HairClone? They are injecting dermal papilla cells only into the scalp.
One last question regarding Tsuji treatment
Be it 2025, what makes you think that Tsuji’s treatment will be successful and will not be like any hair cloning treatment which had failed in past. Just wanted to hear your views on that treatment.
Read their research papers
How could Kay find the admin’s opinion in the clinical research papers?
My response is, people tend to acknowledge the potential strength of Tsuji’s treatment first i.e. the fact that it could reverse a completely bald person to NW0. However, there’s no guarantee that the technology will work, though we do absolutely hope that it does.
Some of us have a life Tom. Your response to Kay was rude, imo
Lol why is it rude.. I was just referring to the fact that the research of Tsuji is way more advanced compared to the research of these companies that failed.
Which companies have officially failed/stopped conducting research/clinical testing?
Ask Kay
Yoda my man, Intercytex is a company which was one of the first ones to trial hair cloning and implement their techniques on humans but they admitted they failed on that project and soon after that ran out of business
Like everyone out here I also want Tsuji’s treatment to be successful but I just wanted to know what is it about his treatment that has an edge over other hair cloning treatments.
None offense taken Tom but I would be glad it you could what “advancement” you’re talking about.
I believe Intercytex was actually bought out and one of their product candidates was successfully if memory serves from a conversation with Paul Kemp.
Sometimes it’s hard to get a feel for a person’s tone and intention through written text.
@ Admin … 3 issues to discuss. Can you maybe check …
1) Avalon Globocare to cooperate with Hydropeptide to develop Exosomes Cosmeceuticals
https://www.globenewswire.com/news-release/2020/04/28/2023367/0/en/Avalon-GloboCare-Partners-with-HydroPeptide-a-Leader-in-Epigenetics-Skin-Care-to-Accelerate-Regenerative-ACTEX-Product-Development-and-Commercialization.html
2) Exocobio to develop Exosomes Cosmeceuticals
http://www.exocobio.com/
3) Allergan acquired by Abbvie … what does that mean for Hair Loss?
https://www.allergan.com/research-and-development/pipeline
短暂的临时反应:谢谢你分享这个John. Exosomes are still up in the air in my opinion but if these companies can produce some tissue specific exosome products for hair growth I would be very interested. Results should be a bit more consistent than PRP I believe. We will just have to follow their progress and see what products come out and with what data.
Abbvie acquiring Allergan does not change too much, they’re just the parent company for Allergan now.
Admin, I think we cannot compare PRP injections in a clinic with an topical Exosomes Cosmeceutical you can apply at home. Also tbh I give nothing for single Treatment results anymore. I really dont get it why still single drugs a used. We know since years Baldness is a multy Factoral desease. So you have to use several different Treatments together like Exosomes, Anti-Hormones, Anti-Receptors, Electro Stimulation, Metabolism, Growth factors … aso …
Eoxsome cosmeceuticals will likely have to come with some strong data to impress people, especially since their clinical counterparts have not objectively shown consistent strong efficacy.
How is this anticipated to work for patients with retrograde alopecia (thinning in the back and sides)?
Intercytex worked and had regrowth in their phase 1 or 2 tria . They were in the right direction. But of course when something good happens in the medical world the treatment gets bought out by a competitor or the company stops for some bs reason. Hop on the big 3 and keep what you got for as long as it works for you. Everytjjg else isn’t guaranteed. Not even tsuji.
Question for admin and anyone else:
On various forums, I have seen people say that they use various treatments to attack hairloss from various angles.
At the moment, I can’t take finasteride (trying for baby) so I would like to try other options. What should I be looking at?
– I got oral minox from derm (just started. Low dose)
– I have foam minoxidil.
– I have Nizoral.
What else should I add to regimine? Oral treatments are preferable, but I’m open to anything that could lead to visible thickening.
Well, beyond minoxidil and finasteride the options are mostly few and far between. You could add dermarolling to your regimen first and foremost and then research if spironolactone is contraindicated for pregnancy as well.
Kay & Friends, Tsuji’s germ-method bioengineers cells that replicate the embryonic development process. The cells become an organ germ and embryonic organogenesis occurs creating a follicle. It is this ‘organ-germ method’ that sets him apart from other research; it mimics normal development—the hair grows correctly and connects properly with the surrounding tissue.
Pre-clinical in 2019. Human Clinical in 2020. So there is a good chance that someone somewhere has Tsuji engineered hair follicles on their head right now! That’s worth getting excited about.
the company mentioning to media that they planned to do human trial in 2020 does not mean that a trial happened or will happn in 2020, lots of companies plan many of things.
Thanks for the contribution Toccata! Though, I’ve never seen announcement that an Organ Technologies trial for hair cloning has begun, have you?
I have confirmation of the 2019 pre-clinical study for AGA. Takashi Tsuji authored a research paper last year in which the following quote appears: “Because hair follicle stem cells are the only adult stem cells possessing organ-inductive potential that can be transplanted autogenously, the first human clinical trial of organ regenerative therapy will undoubtedly investigate hair follicle regeneration. The regeneration of hair follicles using our organ germ method is *now being investigated in a pre-clinical study to cure patients suffering from androgenic alopecia*, with an aim of conducting clinical trials in 2020.” —T.T. for Takashi Tsuji (Functional ectodermal organ regeneration as the next generation of organ replacement therapy. March 2019 issue of Open Biology).
To study the practicality of the method, they must actually transplant the organ germ into a human head. It seems reasonable to believe after more than a year—the article was submitted in January 2019—they have tested on at least one human AGA subject, most likely a small injection site—I believe the mouse study showed 28 organ germ injections produced 128 hairs per cm2. Perhaps one could take the skeptical approach and doubt Tsuji’s credibility, the method, and the timeline. I choose not to.
Thanks for sharing again, Toccata. I do not doubt Tsuji’s credibility and I have good hope for his method, but I don’t believe the treatment has entered a human trial yet. I suppose it’s possible they have may tested something on a private human volunteer, though, there is a risk in doing that outside of a clinical trial, I’m not sure Dr. Tsuji would do that.
When do you expect news from Tissuse/J.Hewitt?
Do you think they will be able to start the trials this year?
I hope they will be able to start this year. At this time, I guess there will be news by the end of July.
One question in this regard – in one of your updates you mentioned a recently published paper related to their hair cloning approach and it was also mentioned that “so far no full follicle formation” was achieved. It was also mentioned that since the paper was written and published the research team has probably/hopefully progressed but considering that a) the paper is not completely outdated and b) the first clinical trials in Japan were supposed to start already in December 2019 it just seems like a big leap to me. I’m by no means an expert, hence I would really be interested in your opinion on this.
Apart from this, do you have other articles in the pipeline we can look forward to? Thanks again for the good work, keep it up!
Vienna, the important factor is we don’t know when that research originally took place, it could be 2 years old or 1 year old. The peer review process takes time from when a paper is submitted until it is approved and published. It’s hard to say where TissUse is at with its tech, but the eventual clinical trial will reveal what we want to know.
I have about 2 new stories which should be coming soon after I hear back from the respective companies, thanks for reading and supporting!
Would be Great!
@FollicleThought why end of july in particular?
No reason in particular, just a proper timeline for business developments to occur.
Hi Admin,
我看到很多和热情谈论那些stem cell treatments like Tsuji’s, J. Hewitt et al. But these methods all require hair transplantation, which might not be suitable for everyone.
A better solution in my opinion would be to induce hair follicle neogenesis directly in the scalp, much like Follica is doing. There was a study from a few years back that achieved that as well by using 2 molecules applied topically (on mice of course).
I wonder, are there any other companies that are working towards that goal? Or are stem cell solutions solely focusing on harvesting existing hair, duplicating and re-implanting?
Many thanks!
http://www2.riken.jp/dmp/english/contents3_en.html
The trials didnt start
Nils, the pipeline you linked is dated March 26, 2019 and the last webpage update was June 7, 2019. There’s no knowing whether they began trials in 2020, short of asking someone working in the lab.
where is date of pipeline listed?
Click on (List of themes and projects can download here.) <<<
It is the PDF version of the pipeline. March 26, 2019 — bottom of the page.
你好管理员,
Please tell us about the new JAK inhibitors for alopecia areata and how effective they are.
I appreciate what you do.
I just stumbled across a site called Copenhagen Grooming. They sell beard-related products, including a kit which makes interesting claims about increasing facial hair density.
The kit contains an Activator Serum, which contains “two bio-active ingredients: Biotin and Capilia Longa. Micro-needling will help these get deeply absorbed in the follicles and optimize the boost of new hair growth. It does so by activating the dormant hair follicles that lie in a resting state underneath the skin.”
Does anyone know anything about Capillia Longa? I was going to buy the kit (£69) in the hope that it would increase my beard density and maybe help my hair, too.
Anyone else heard of this? Worth a try? Or snail oil?
There are a lot of poor reviews about this online. But they do offer a no quibble money back guarantee, so no hurt in trying. Here is one review from Reddit….
Bought the product 1,5 month ago. Might even be 2 months ago. I don’t know. I also just created this reddit account just to make this post, because I just have to give a review on this product and let you guys know of my experience so far.Things i have noticed:- All their reviews on trustpilot are from users with only 1 review indicating the reviews are either from friends or bots. Haven’t seen 1 legitimate review. Also, i’ve been spammed with facebook ads on which there are just comments of guys tagging each other. No real comments are made from people who have actually used the product leaving feedback or asking questions as if the admins of the fb-page are deleting the negativity there
– Their marketing videos on their site makes me sick. They only show pics and vids of people having insanely thick beards being SHORT where we see them use the roller and then “poof”… suddenly they show a pic of the same guy who has just grown his hair LONGER but definitely not thicker. This is misleading af! no before/after pictures.
– I bought the product even though it was shitty expensive because I couldn’t resist :). I think I got 4 items worth 5 usd in materials!!! bad quality and barely anything in the serum container. How can that be 600dkk ?????? wtf – their margins must be huge.
– Have read a lot of customers doubting their “clinical study”
My experience so far after using it for approx 2 months is that I can’t really see any difference…. But ill keep using it until the containers are empty just not to waste 600 dkk.
Hi!
Could you please share any info (if there is any) about Alopecia universalis treatment? I’ve heard about JAK, but when I read the articles about them I understood that the percentage of recurrence even during treatment is high. Are there any new interesting studies/trials concerning combination of JAK with anything else or better understanding why in some cases it doesn’t help? Need something to hope that there will be a treatment in some years. Thank you.
Hi there Max, I haven’t heard of many new alopecia areata/universalis treatments other than JAK inhibitors lately. There are a few immunotherapy companies who talk about potentially working on areata in the future, but I don’t know of anything really getting into a clinical trial presently. I’ll keep an eye out on this subject.
Also, just letting everyone know there will be some new content coming this week. I’m just waiting on the responses of a few companies.
how positive on a scale of 1-10?
The only interesting news are about TissUse and Tsuji.
We don’t need another 20 companies with lotion and combover pictures.
是乔恩·奈特告诉丫,尤其这一切吗EIDO who fets against j hewitt that they can’t find a CPC? Or is it also Tsuji?
Olaf all that admin’s doing is providing the best possible news to us. You can appreciate the work done by him or stay quiet.
Yoda is holding his fire Joseph!
LOL thanks Yoda
I truly appreciate your kind and intelligent words Kay, thank you.
High five to you, Olaf!
C and Olaf, if you’re not interested in reading the articles that aren’t about TissUse and Tsuji maybe you can hold your hand up to your monitor and block them out while your browse the site.
Haha can I do that to my hairloss when browsing in the mirror?
Haha, sounds like a decent idea Mattt.
any thing coming out of australia for hair loss strange that I’ve heard zero nothing !
2022世界杯附加赛预测英格兰vs美国皇冠比分卵泡认为我怎样才能变成一个头发克隆trial or how do I get into phase 3 of Follica’s trial? Clinical trials.gov?
Woofy, the best bet is to contact the company doing the trial you want to be involved in. There’s no cloning trial in US planned (if you’re US) and Follica has not announced a phase 3 yet, but they are imminently going into a phase 3. You could try contacting their parent company Puretech Health.
Hi Admin. I read that HairClone closed due to Corona Virus in March if I’m not mistaken. It’s been a long time since then, do you know if they have opened up?
John, HairClone is doing research in the lab. I believe I had an update on them in the Updates page a few months ago if you want to check it out.
你好管理员,
Any new results for hair cloning,when will available? We hope as soon as possible!?
HairClone should have an update within 2 months on a timeline for availability in the UK, thanks.
Are we still expecting an update from HaireClone in the next few weeks?
Yes
Just thought I’d update this. The CEO of HairClone said they would be starting human trials in early 2022 in the UK in their own Hair Clinics and partner clinics in their network!
Thanks Sonic, where did you get the transcription?
You’re welcome. We’re all here to share information because we’re all chasing the same goal
A person from another forum actually DM’d the Chief/Senior Scientist for HairClone Jennifer Dillon on Instagram. And according to him, she was super down to earth and really helpful with giving this information. Which is quite nice.
She seems like a genuine good person from her Instagram account. Which is good, unlike some of the conman that can be in this industry.
I also came across this new Question and Answer!
“I got a few very answers from their chief scientist! She seems to be quite a nice person who actually cares about baldies. Here are the most important questions and answers.
Q: May I ask you a question? Did you guys gather any evidence so far that the treatment actually works on humans? As I guess similar methods like Intercytex had mediocre results in humans. However, I think what you are trying to do is to do 3d culturing such that the cells do not lose their inductive properties, i.e. can be used for hair rejunevation.
A:
Thank you, I really think what we’re doing could really help. There is evidence in mice and in humans that this works. Mouse work is not really great because human hairs are quite different but the work Aderans research did showed some good effects. The CEO of Intercytex is the CEO of HairClone. I am quite new to the business world, but it takes more than just good science to be successful. Back in 2003(ish) they were trying to grow new hairs. They did not show many new hairs but showed thickening of the hairs that are starting to become thinner. Because this was not their primary end point, it was not deemed a success. The difference now is that we are targeting hairs undergoing thinning, not trying to make brand new hairs. A clinical trial can succeed or fail based purely on patient selection. We will be much more informed on who to select going forward and therefore much more likely to show it works. The ones that are still actively miniaturising are what we are targeting. Those ones become thicker. In the trials that went on, they chose people with bald patches mainly. We believe our therapy will help those that have just started to thin restore and retain thick hair. It’s fascinating to see things from the business side too. I thought “why would they drop this approach if it is showing success?” And the answer is a) it didn’t show much NEW hair growth, which is what they were aiming for and b) the company was bought by a company who made a lot of money from wigs and hair transplants (Bosely). Research is expensive so they dropped it.
It is difficult to get funding to do this work because it is considered cosmetic. And I have had messages saying I should do something more important like cancer research or heart research. Funnily enough, I spent 10 years doing cancer research and feel like I have a better chance of actually improving peoples’ lives doing what I am now. I also get a lot of messages from people who are depressed and have low self esteem because of hair loss. It’s a large part of a person’s identity. I can very much relate.
Q: okay a question I’ve always asked myself is pretty much (not directly related to your company though): Do you think that hair follicles just go dormant or they actually “die”? I think I have seen a few cases on transgender women who have regained a lot of their hair after years of baldness.
A: Hair follicles seem to keep getting thinner and thinner until they just don’t have the capacity to generate a hair anymore. So i believe there is a residual follicle there, it just doesn’t have the capacity to do anything.
Transgender women are the only people who can get hair transplants on the NHS. For the very reason that it is so fundamental to a person’s identity
Q:
I see! Wow I am actually very impressed by how much you care. I do not know if you are aware of this but there are a few blogs dedicated to hair loss which wrote about your company (folliclethought/hairlosscure2020).
A:
I’m very motivated by the thought of helping improve so many peoples’ lives. It bothered me that cancer research is all about extending life (because it’s a definitive measurement) when really quality of life is extremely important too
Follicle thought is excellent. Our CEO talks to Joe quite often to give him updates
Q: There was quite a hype when the Ceo announced that you would start treating patients early 2022 in UK only, but obviously there was a little bit of scepticism, because there weren’t any new treatments since rogaine/finasteride were approved 20+ years ago, and there was a lot of straight up charlatanism in the next decade. I suppose people tried to monetarize on people’s fears too much, this is why I think there is some scepticism on a treatment which did not show efficacy on humans yet.
A:
It’s horrible how many people just lie and say they will be able to treat people soon when really it’s years away. Unfortunately, Covid got in the way of us validating our cell growing method in the manufacturing facility, which was due to begin July. Once validated, we can start to test in people in the UK. I do not blame people who are sceptical when so much has been promised. The issues lie in funding the test treatments, but once efficacy has been shown, I have no doubt things will take off. We need to work to make the process more efficient and less costly.
Q: Yeah people are super sceptical for sure, but I guess when the results are there they are there, right.
A: Yes, we just need to convince people with money to pay for the experiments to show that it works! That’s the barrier
Q: yeah, I mean this probably depends on the price right? I wouldn’t spend 10k too if I don’t know if it works, but I guess people waste thousands of bucks for prp, so why not give it a try at least?
A: Well, to begin with, we need to test on people so it’ll be free to them, but the money needs to come from investment somewhere! Then if it’s successful, we can charge and go from there.
Q: I really think things start to look promising! There are many companies and angles this problem is tackled from. I cheer for you guys (and Kintor, hope they manage to create an antiandrogen without side effects)
A:
I wonder whether finasteride injections could provide that. That would be great! There are shampoos that claim to block DHT but they do not. There is so much false information out there when it comes to hair loss. Quite horrible.”
This sounds like a a lot more realistic approach and far more likely to work.
Hi Follicle Thought,
Based on the information that you have do you think these stem cell therapies like Hairclone, RCH – 01, EpiBiotech, HanBio can be used as monotherapy in order to stop further hairloss?
I understand that regrowth is probably not to be expected but would they be able to hold progression of hair loss without having to use finasteride or minoxidil?
I think it’s definitely possible Jade.
Thanks Follicle Thought,
当你觉得Hairclo的服务吗ne would be available in the UK?
I remember in a video interview with Paul Kemp from October he said they are aiming for early 2022, but in your pipeline you have listed it as Q3 2022.
Do you have an update on their timeline?
No update