Updated on March 24, 2022
New Hair Growth Cosmeceutical Using siRNA With Published Study: CosmeRNA
Bioneer Targets H2 2022 Euro Launch Of CosmeRNA: Update (3/9/22)
Bioneer/siRNAgen has apparently been evaluating its CosmeRNA product for cosmetic regulatory approval in Germany over the past several months. Various news outlets in the Korean pressreportedon March 8, 2022 that CosmeRNA has received an “excellent” safety evaluation by Dermatest, an accredited agency based in Germany. According to reports, siRNAgen plans to receive a 5-star cosmetic ingredient rating in the second half of 2022 which would lead to the European launch of CosmeRNA.
Original Article
siRNAgen Therapeutics of South Korea is planning to launch an over the counter product to treat male and female hair loss in the United States.
Topical Androgen Receptor Suppressor By Small Interfering RNA
CosmeRNA is a siRNA therapy intended to treat androgenic alopecia in men and women. The product was developed bysiRNAgen Therapeutics, a company specializing in RNA interference technology, based in South Korea. siRNA is a therapeutic technology which stands for small interfering RNA or silencing RNA. In short,siRNAtherapies deliver specific RNA sequences into a target area and interfere with the expression of intended genes by interacting with and preventing the translation of messenger RNA. In the case of CosmeRNA, the siRNA is used to suppress the expression of the androgen receptor gene, thereby limiting the number of androgen receptors within hair follicles. Consequentially, decreasing androgen receptor sites decreases opportunities for the hormone DHT to bind to hair follicles and degrade them.
SAMiRNA研究发表的Nature
Without getting too technical, the proprietary technology developed by siRNAgen Therapeutics is called SAMiRNA (self-assembled micelle inhibitory RNA), it is their own version of a siRNA therapy. On January 31, 2022, the study “Weekly treatment with SAMiRNA targeting the androgen receptor ameliorates androgenetic alopecia” waspublishedinScientific Reportsof theNature Portfolio. In the publication, the team from siRNAgen Therapeutics led by Dr. Han-Oh Park tested two concentrations of AR-68, a SAMiRNA intended to suppress androgen receptors. Two separate clinical trials were completed to evaluate the different concentrations of AR68 in male and female subjects. The first cohort of treated subjects received a low dose of AR68, specifically 0.5 mg three times per week over the course of 24 weeks or 6 months. The treated group comprised 22 males and females with a mean age of 42 years old. At the completion of thefirststudy, there was an average increase of 2.2 hairs per cm2among treated subjects and there was no recorded difference in the self-assessment between treated subjects and those who received placebo.
The second cohort of treated subjects received a high dose of AR68, 5mg once per week over the course of 6 months. This dosing proved to be more effective than the low dose. The second treated cohort also included 22 male and female subjects with a mean age of 44 years old. At the completion of thesecondstudy, the treated group showed an average increase of 7.7 hairs per cm2, while the placebo group showed a slight decrease in total hair count. The treated group also responded positively in the self assessment questionnaire. In both the low and high dose studies, safety was good. The study’s abstract also mentions that high dose AR68 performed 83% as efficacious as finasteride when compared to a specific study of oral finasteride.
Seeking CosmeRNA Partnerships In The United States
According to acorporate presentation, siRNAgen Therapeutics is currently seeking partnerships or out-licensing opportunities to market CosmeRNA (AR68) in the US as an over the counter product in 2022/23. This improves the attractiveness of CosmeRNA as a treatment option in my opinion. While the results attained in the study are not jaw-dropping, they represent a potential option for those who cannot tolerate finasteride or those who want to add onto their hair growth regimen. I am surprised that siRNAgen is seeking to offer their siRNA therapy as an OTC cosmeceutical product, however, one would assume that they have a confident understanding about such possibilities. A news update on the company’s website also mentions positive feedback which was received for CosmeRNA at the JP Morgan Healthcare Conference 2022 and that the company is also planning to “improve the product profile” and develop AR68 “beyond cosmeceutical use” in the US.
What do you think of CosmeRNA? Would you use the product if it was released as a cosmeceutical this year?
Big thanks to reader John Doe for the tip.
2022 so far, yay or nay?
Yes i would try the product if it did not contain minoxidil
I used minoxidil for maybe two years and developed a chronic intestinal problem. I dont use any pharmaceuticals and l attribute that condition to minoxidil.
Will this be something like Eucapil fluridil) that you can get off Ebay? If say a South Korean company already has it? Since it might be long time for the FDA to ok it
如果它被发布在韩国我想象你可以then get it off Ebay..
would be awesome, since fluridil works quite well. It’s binding affinity is better than breezula for instance.
I might help you, if it gets launched in Germany, text me on Telegram:https://t.me/+WiHfioVpH6Y4NDEy
How does this fare with the already existing solution like Minoxidil?
I don’t remember the minoxidil numbers off the top of my head for a 6 month study, but I imagine that minoxidil is a little better around 6 mos. That being said, CosmeRNA shows a noticeable thickening effect at the hairline of the subject in the photos.
Is this already available in South Korea then?
However it doesn’t mention the side effects.
For the studies, it does mention side effects, YoYo. I don’t think it’s possible for them to speculate on long term side effects from the product.
Of all participants, there was one subject who experienced redness, swelling, and itching at the treatment site. The dermatologist which treated the patient somehow “determined that the relationship between the symptoms and AR68 was slight”, for what it’s worth. See “Safety assessments.”
I see thank you FT, the likelihood of this being available in the US this year or next year does seem low though right?
That all depends on partnership interest and $. If siRNAgen knows that the concentration of their therapy is possible to be marketed as an OTC then it’s simply a matter of finding a partner and getting the final necessary study done for the FDA. Then you bring the product to market.
FT-on the other hand, wouldn’t this drug be better for halting hair loss vs minoxidil?
It potentially could be Josh, I understand your point but I don’t want to go out on the limb too early.
Where can I buy this product is it fda approved
If and when CosmeRNA becomes approved for marketing in the US I will definitely share the information on the Updates page or here Valerie.
Thanks Admin! … the good thing is you use it only once every week. And you can use it additionally to Fin or Minox. … 2022 starts very well. Seems like we get a new Company with new treatment every week now and the Trials we already know make good progress.
May be 2022 will be the end of the hairlost! Hope so
Thanks FT for the shoutout on my hair system research. Everyone- The lavivid hair systems are not realistic looking in my opinion and same with the other brand called hairskeen (unless you have a good stylist) that can fix the hairline but most of the time it looks so fake on the scalp the hairlines are Literally straight lines and do not look natural. Some men the crowns look unrealistic they look like mushrooms obviously placed on the scalp to cover the crown that’s why I started doing research on hair systems. If you get a hair system make sure the color matches 100% and make sure you have the correct texture and density. Density is very important i’m seeing alot of guys that get hair systems on social media and they all look poofy way too much hair on top. Color, density and texture all have align perfectly.
That’s why I like the wig makers that make wigs for films if you get it from them and then find a really good stylist you’re in good shape because they look more realistic then what the mom and pop shops are able to offer you.
没有问题在shoutout粗直浓密的,如果人基于“增大化现实”技术e confused about you bringing it up, it’s because I gave you the shoutout in another article’s comments I believe it was the Fukuda Lab article?
i think so.
Hey FT I had a quick question. Because dNOVO had demonstrated that they could convert human skin cells directly into induced hair stem cells without going through a pluripotent state. Could that mean that their FDA trials could potentially be faster than say Stemson’s?
I honestly don’t know the answer to that YoYo. I suppose, it depends on who gets into a trial the quickest.
If you liked the article you may be interested in a previous siRNA therapy candidate for AGA and chemotherapy induced alopecia. >//www.tokobukuku.com/quark-pharmaceuticals-wchr2017-presentation/
Back in 2017 I had an exclusive from Quark Pharmaceuticals who developed a similar androgen receptor suppressing siRNA treatment. At the time, Quark had partnered with a Chinese company Suzhou Ribo Life Science Co to develop a cosmeceutical version of its therapy. Apparently, that project has still not come to fruition and Quark’s website is down these days.
Also, if you did not get an email notification letting you know about this new article – why aren’t you signed up yet?
Sign up for email updates in the right sidebar on desktop browser or at the bottom bar on mobile browser.
Interesting, thanks. I am getting the “yet another cosmetic that sounds too good to be true” vibe but maybe I’m wrong. If it actually works, then the big question would be how does it interact with existing treatments. I wouldn’t compare it to minox, but would the effect add up to what we can get from fina?
Thanks for all the work you do FT. I really appreciate the commitment to delivering research updates with speed and detail.
Thanks gc
Great news, thanks FT! I can’t see it getting through the federal regulatory gauntlet within the year, but it sounds promising. By the way, didn’t you mention something about Rogaine working on an enhanced application a while back. Anything new to report on that front?
I’m not sure if I mentioned anything about Rogaine working on an enhanced product, but I do hope to share some helpful news in the near term.
Hello FT,
First off, I’d like to say thanks for this article, it’s very exciting to see new things that could help with hair loss. OTC products may not be big game changers but you never know. It’s good to be hopeful. And I think what Matthew Grady was talking about was the minoxidil booster, I could be wrong but that’s the only thing I could think of. I know I bothered you a few times about that, in the past, is there any word of it being released this year? I saw on their site it said 2021. Just seeing if that was still in the works. Thanks for your hard work.
Cheers
Thanks MasterV. I will reach out to Dr. Goren today about the release.
MasterV, apparently the company DanielAlain will be selling the product at some point. They’re selling the minoxidil test now. I don’t have a sense of when for the booster though.
谢谢你的更新英尺。希望他们释放the booster sometime this year. I’d like to give it a shot even through it may not be a big changer. I responded fairly well when I first started minoxidil, but it seems over time it hasn’t given the same results. So maybe this booster can help out. Thanks
This being an over the counter product in Korea,… Does this mean we can easily import it and don’t have to wait for FDA,… to approve it first?
Peterson–I am also curious about this. Perhaps I will exchange this for stemoxydine; also because I am allergic to minoxidil.
I’m not sure if this product is for sale yet in Korea, but within two weeks I should have more information on that.
HYPED
Hi Admin, so if I understand that well this product should grant you maintenance but not improvement, right? I mean, if you start it in time it would freeze your situation as it is, right?
If it didn’t have side effects it would still be a good option…
Bill, it’s definitely a potential what you say about this product maintaining hair but not adding too much regrowth. But, I’m just not able to confirm that this could “freeze” a situation because it’s new and hasn’t been tested by enough people yet long term.
It is starting to get ridiculous. This January held what I hoped for for the whole 2022! I truly think it is time to be optimistic. Until 2027, we actually might get safer and/or more effective treatments than our good old Fin and Minox.
What do you mean until 2027 sorry?
Bro! We are in the same team. We just want our hair back and live our lifes sorry if I came across rude before, I apologize! However, unfortunately I think a lot is pointing to the fact that Stemson will need a few more years of R&D. Geoff said that in an interview with this site, Alexey indicated that in 2020 (you even said that I don’t know where the science is at but then said that the opinion of their chief scientist is pointless? :P) After all, its two strangers arguing about the progress and market availability of a pre-clinical ipsc-based company anyway and has zero relevance on anything At this stage, it is very, very likely that they fail anyway cause 1) most pre-clinical work never sees the market and 2) there aren’t any ipsc-based therapies out there today, so lets be real and think about how likely it is that cloned hair are growing on our head in a few years anyway? I would say that since AGA is theoretically reversible for many years, a treatment reversing the minituarization like the Bayer Prolactin antibody seems like a rather practical treatment in reach. any case man, keep your head up, there is a lot of research going on right now and I dont think this will change anytime soon
Blave—very good month indeed, but my hopes go beyond this for 2022. At least some updates from kintor and hopefully breezula.
Don’t forget dNOVO and stemson!
Yeah kintor phase 2 results would be great and Breezula phase 3 trials starting!
And concerning a final solution, seeing some form of Stemson progress always feels good, maybe first pig data?
Blave—for sure, that would be some nice widespread developments in different areas in hairloss research. We’l see, I have a careful hope that we are seeing some breakthroughs.
Apparently, Stemson has added two great scientists to their SAB. This is great! But I feel like the last sentence indicates that they have years of R&D in front of them (followed by 6-7 years of clinical trials..). Unfortunately, this is realistically about 12-15 years away, 4-5 years of R&D, 6-7 years of clinical trials, 1-2 years of market entry. What a shame I wasn’t born 15 years later
Geoff Hamilton LinkedIn:
I am pleased to welcome Dr. George Murphy of the Harvard Stem Cell Institute and Dr. Kapil Bharti of the National Institute of Health to the Scientific Advisory Board at Stemson Therapeutics. We are lucky to have these two world class experts guiding us in the coming years!
嘿,blave,你意识到,如果Stemsoncome out and they are wanting to release their product 12-15 years away that the funds from their supporters would stop coming in. No company would be supporting a biotech company with that kind of roadmap and they’re pumping that much money in with an end result that late. I believe “in the coming years” doesn’t mean 15 years away lol, I’m sure he means the years inclusive of finishing the pre-clinical, human trials etc, it’s a vague statement not meant to be interpreted as a century away lol. If anything they have to release within this decade in order for them to continue to receive funds and show the progress they are making, otherwise the supporters would be losing money for no reason.
Why do you think the funds would stop coming in?
Because think about it, why should an investor fund a company millions of dollars when that company isn’t make significant progress over a period of time. If you were to tell your investors that we MIGHT have something for you in 15 years but we still want you to fund us, the investors aren’t going to feel confident on spending that much money over such a long period of time on a result that might or might not work out. That’s why it has to be within this decade in order for them to continue getting their funds. And the fact that they’ve hired a doctor who is using iPSCs and is undergoing clinical trials is only a positive sign that it can only accelerate Stemson’s timeline.
I see yes. I read this statement often. And maybe its true. BUT those are professionel investors. Every investor knows that investing in startups is high risk high reward. And whats even more importent – they dont calculate like privat people do. If they see a chance and it lasts for 15 or 20 years- they are fine with it. For a big company 15 years off waiting is totally fine.
Even privat people invest money in stuff which takes 10 years or longer just to get their money back.
I think as long as they can show “at least some progress” and if they confince the investor to keep waiting, companies like stemson can reaearch a very long time.
(As long as they dont show that their reaearch does not lead to any success)
Who knows – time will tell
Quite honestly, I think you’ve made a good point! It is indeed promising that this doctor is undergoing clinical trials is amazing. And with all the money Stemson raised, their amazing exectutive team (I think Geoff does a stellar job as their CEO so far and Cenk seems to be incredibly capable and smart too, and obviously Alexey invented the whole thing), their 15 R&D Scientists including amazing,amazing scientists (I myself am a Data Scientist and was absolutely humbled by the references of their Data Science director), and their partnerships with industry, the great SAB, the partnerships they have with TU Vienna for 3D printing (https://tiss.tuwien.ac.at/fpl/project/index.xhtml?id=1870665500万年),22日,the only hair cloning company in human history who actually do have a shot. I admit that! Still, I believe the problem is incredibly complex and it is likely that they fail.
And also think of how fast Stemson is getting their funds, they received $7.5M seed funding in 2020 and in 2021 they received $15M for series A. And already talked about human trials and funding for series B once their pigs pre clinical finishes. Improvements are being made at a steady pace which is allowing them to receive the funding, required for them to be operational.
„blave“ is talking absolute nonsense although he phrases it in a logic way.
Nobody would get any funding for a 15-year-project – how ridiculous. Pig testing is already being done and if successful they will start a Series-B-funding and immediately after that the start of human trials. How long does that take? I don’t know…but a start of human trials in 2023 is absolutely possible. And if that is successful they will plough through the timeline because they will be shat on with money. Another factor is the competition, Hairclone, HanBio and Epibiotech are starting this year. Tsuji still there, TrichoSeeds the new contender in 2023.
Besides: because of the longer timeframe of the allogenic solution they already work on an autologous one.
Stemson is the real deal with 20 staff members and a world-class collaborators…I am grateful for their project, it’s by far the most promising venture in the industry.
I honestly wish I would lol. Truth is that biotech investments are highly speculative and you absolutely expect most of your investments to fail, but then you get one blockbuster treatment which ultimately makes more than up for it. 10-15 years i an absolute legitimate timeframe. Clinical trials alone take on average 6-7 years. Pig Testing is done is good news for sure but the company executives themselves dont get tired about telling us how many challenges they have to solve still. You guys are very emotional, but the truth is that anything under 10 years is extremely unlikely. I absoultely agree that Stemson is by far the best contender and I really hope that they dont do their clinical trials in the US but somewhere else where market entry is easier. They honestly don’t have any rivals as Hairclone, HanBio and Epibiotech are all absolutely amateurish. Hair clone is not even working on hair cloning right now lol
Even after the destruction of ARs in the HFs , its only 83% as effective as fin? Well that’s weird. Is it because its a topical treatment or we are slowly realising that DHT is not the only culprit.
Shayak, I would imagine that a topical treatment or even a systemic treatment (if it were possible) would still not necessarily suppress every AR in the body or a hair follicle. Just like finasteride does not completely eradicate DHT from the body. DHT is likely not the only culprit but DHT creates problems that go beyond limiting DHT in order to reverse. For example, once DHT has degraded the dermal papilla niche past a certain point, then even removing virtually all DHT will not get the pathways and the cell cycling back online. This is basically the reason why high doses of fin will not restore a Norwood 7. You would then need to get the stem cells cycling again and then suppress the DHT.
83% as effective as Fin, topical, once a week and (allegedly) no side effects, does it sound “only” to you??
Sorry if this sounds pessimistic. But is there actually any improvement in the different photos there? It doesn’t look like any hair has grown back does it?
@John Appleseed Nope, it is supposed to be maintenance, not improvement. It wouldn’t be that bad either if it worked and have no side effects.
If I’m looking at the hairline set of photos from baseline to 24 weeks and I look at the right side parting of his hair, absolutely it looks like there is more hair in the 24 weeks photo. That right section is more see-through in the baseline photo. For the vertex I do not notice any visual improvement.
FT, it would be awesome if you could get some additional information from them on their plans for commercialization in Korea. As a cosmetic there shouldn’t be any reason we can’t import this stuff.
Working on it
Yes that’s fair @FT. I guess it’s only a timeline of 6 months and you wouldn’t actually see that much growth for fin either in that timeline.
Quite honestly, I would be suprised if hair cloning would become available within our lifetimes, the technology is still in its enfancy. I think at some point we will get better maintenance treatments and stronger growth stimulants than Minoxidil, but for a Norwood 7 in his 20s/30s today the only way to ever have hair again is a hair system
It would the cheapest option. If you have a lot of money to spare, you can think of a full HT+ micropigmentation; although you wouldn’t want to be too ambitious then and perhaps go for a norwood 2 with less density.
Were men as bald 100 years ago as they are today. What happened and why is so difficult to reverse especially with all the technologies out there. We can send cancer into remission, clear most skin conditions, re-attach severed body parts, change eye color but can’t find the process that causes hair follicles to shrink. I have hair growing on almost every square inch of my body. The only place it is not growing is my eyeballs. Yet it wont grow on the top of my scalp. So cruel.
Well we did, its dht. You can prevent it with a great drug called Finasteride. Go check it out!
Great article Follicle Thought,
Do you think the company would conduct more studies so we can see how their treatment compares to fin long term (over the period of 1 year or more)?
Also are the 2 studies which the company completed considered as Phase 3 studies? I suppose they didn’t have to go through preclinical and Phase 1 and 2 since South Korea has a different system?
玉,我不认为他们会做一个1年的学习。Seems like a costly study. The studies which the company completed were along the lines of “pilot” studies, just the beginning. I’m in the process of learning about Korean regulations. The product is AR68/CosmeRNA it does not contain minox.
By the way, does this product contain minoxidil?
Thanks Follicle Thought,
Do you think this product might be a substitude for finasteride in order to achieve long term maintenence without side effects?
The only thing I didn’t understand from the study is how is their product a topical but they still manage to not get it go systemic.
I don’t think this product is equivalent to finasteride in its current form, it seems lesser. Exactly how much lesser, I don’t know yet.
FT when stemson is going to do human trials would you help me get in contact with them? I may like to join the trial if alexey feels confident the cells won’t become cancerous.
Woofy, sure when Stemson starts a trial in the US I will share about the trial on the site and anyone interested may contact them.
Ok great
https://www.youtube.com/watch?v=dLMU2JnGkDo
new interview with Geoff Hamilton coming soon! Probably not too much new information, but I will watch it.
Thanks blave
Pls guys, ask in the comments about clinical trials
Curious, did you read the Follicle Thought interview with Geoff several months ago? That question will not be answered until at least successful pig studies are announced.
There is no significant hair growth when you look at the pictures wtf is that? Is this a Joke? I am not pessimistic just telling my opinion
We’ve all noticed that there is not significant regrowth, however, if you look at the high dose hairline subject (like I’ve mentioned in a previous comment) there is a clear density improvement. Nothing to be said for the vertex subject, though. Also, there is statistical data which recorded a +7 hair per cm improvement.
I have a question on Kintor. Will the two products that they are working on be able to regrow hair. For a Nw 7 . Is there atleast the possibility that it is able to do that. Or is there not much information about it out yet?
I think it’s possible that some minimal hair could regrow for a NW7, but I confidently feel it would not fully restore a NW7. The effect is hopeful to be in the realm of finasteride, perhaps GT20029 could have slightly better efficacy in a best case scenario – in my opinion.
Stemson’s CEO will talk about a potential timeline.https://youtu.be/r2hJ1Ybg2JU
好了溜溜球,我认为我已经看了这个视频you were right, they will start clinical human trials any moment now.
Yea Blave, I’m hardly wrong when it comes to life in general. I don’t believe human trials will begin this year, most probably later half of next year (best case scenario) and hopefully they do their human trials elsewhere, such as Korea, Australia, Canada etc. FDA often times drag things out unnecessarily.
I have seen the videos as well. (Not an english native = thats why i ask.)
What makes you think they ll start soon? If i understood him right, he was talking about several years before clinical trails?
So he talked about having to take a couple of years (usually means 1-2 years) for R&D, which basically means doing as much research on the pigs within the 1-2 years. After they are confident in their pig results, they will receive series B funding for human trials. And if the human trials were outside the States the process could take even shorter. But he thinks that too will take 1-2 years as well for human trials. So all in all 3-5 years based on what he said in the video.
我的意思是需要1 - 2年的人体试验finish. Again that’s what he said.
They totally don’t need to figure out a thousand things and I totally won’t get a hair system and forget about their existence for the next decade
That was irony :/ this will unfortunately take a lot of years.
It seems like the CTO of Stemson isnt part of the team anymore.
Where did you find this from?
From their Website Stemsontx.com, then on “Team” you see that he is no longer there and someone else is now in the executive team..
Yes true. I hope that is not a bad sign.
The guy (Cenk Sumen) was responsible for all the technological stuff outside of biology and the lab.
Robotics, scalable cell-culturing, mass production, machinery.
A key-role for scalability. Could have been totally planned though, as „Dark Horse Consulting“ is already involved in the development of those critical tools.
Website of Dark Horse Consulting:https://darkhorseconsultinggroup.com/
hopefully, stemson will be cheaper than Tsuji. its a shame insurance won’t cover hair transplants. I’ve always said don’t worry about the price just be glad it is an available option when it comes out but honestly, now the price is a concern lol
100% cheaper than Tsuji. Weren’t they asking for $250k lol . Plus they had no investor backing, no clinical proof etc. Stemson I’m guessing will start off as $40-$50K and over time decrease in price until it gets to a price of a regular hair transplant.
40 to 50k? I hope your guess is correct that’s not bad
aaaand it starts again, the downfall of the next “promising company”, it really is a never-ending circle, it is just a too complex problem for our current technology. That’s it.
blave, I honestly don’t know what your comment is in reference too, but please try to keep things reasonable. The sky’s not falling; objectively, the industry has never looked better. Solutions are not guaranteed but they are more probable than not, and I think that’s the first time we could say that. Do you know any wealthy people who could invest? Can you think of any ways that you can support the development of therapies?
Wait a second, blave are you froggy7?
Ok I removed one of the comments. Please be respectful YoYo.
Yeah guys I will give up and shave. I wish you all the best still! Thanks folliclethought for the great work over the years:)
Good luck, Blave and best wishes.
Check this one out josh I think I showed FT this a while ago? Anyways this is a good result the color, density, style all align pretty well.https://www.instagram.com/p/BwSDYjnhV_Q/
Looks great for a hair system Woofy. Even is slightly thinned at the part for a realistic effect.
The recovery of the first woman and the third person in the world from the virus that causes AIDS after a stem cell transplant. I think the key to treating baldness is stem cells
任何更新在Ko如果已经可以买rea?
I did not receive a reply from the company yet. I imagine many the representative probably received a lot of emails from the crowd when the article published. Sometimes that deters them from responding at all.
Thanks please keep us updated on this one I’m really interested in buying
Sorry ,
I can’t realize any different between photos.(before using and after using ،)
Is there?
Shery, I added a photo to the article. Please let me know if you notice a difference in the photos.
I appreciate u for your attention.
I saw the photo bottom the article,after 24 months I think not noticible.
What is other people’s feedback at the photos at the bottom of the article? Personally I see a clear difference. I won’t go into how impressive it is or not, but a difference is clear.
Hey FT, Hope you’re doing good. I was wondering if you were going to do an interview with dNOVO sometime? Thanks again for the work.
I have completed a small interview with dNovo. The information shared at this point is not crucial but I will share it in a week or two.
酷由于英国《金融时报》
How many people came to this site to see the dates, hoped but their lives were not enough and died.
I’ve heard retinol can speed up AGA. Does anyone know if ceramides speed up male pattern baldness?
Have you seen this study Woofy?http://inhumanexperiment.blogspot.com/2010/06/topical-retinoids-grow-hair-in-humans.html
Hi FT, I haven’t seen that study before. that’s interesting
Hello Admin, in my region this product is becoming popular:
https://adonhaircare.com/shop/adonhaircare/adon-product/neo-hair-lotion/
If you search on youtube, people have uploaded their 3-6 months results. This is made in Thailand. Don’t know what is special in this product, but company says it is all nature. I did ask here to doctor (same who own this website i.e. adonhaircare), he says it contains Minoxidil.
Can this nature product be that effective as i see on youtube?
I decided to watch only one video on Youtube, which showed a guy going from basically NW7 to full dense regrowth over a period of time. Typically, minox and fin cannot accomplish that type of result. I can’t say whether the product is useless, but I do not take any value from the Youtube videos.
I agree with you.
Considering cost in Thailand it is very cheap. I mean with this cheap price it would be costly for company to use any other content except Min or Fin.
I am surprised to see this.
hi FT I started taking fin in august of 2017 and continue to take it every single day I’ve never missed a day. I’m coming up to 5 years and I’m worried fin will stop working soon are there any other long-term studies that have been conducted in western countries? I’ve only seen the Japanese 10-year study with 500 men and a 2011 study i think it was only 5 years though and i forget where it was conducted. i’ve been dealing with this bullshit nightmare since November of 2015 when i was in Senior high school if i lose more hair soon i’m going to get a hair system and beg my doctor to prescribe me dutasteride since i can handle fin so i don’t think i’ll have any sides from dut.
https://www.instagram.com/p/CWZmrnZtvOr/also here’s another hair system before and after
why dont you a hair transplant? I believe you have 24 years true?
Jose yeah I’ve looked into it and I can’t get one now because I’m destined for NW7 both uncles on mother’s side my dad is Norwood 3 vertex. When I went to see doctor Alan bauman in 2017 he told me I was Norwood 5 they used the hair check device also to measure miniaturization and so I’m on fin I’ve gone from a Norwood 5 to 3 vertex but the front looks terrible if I get a transplant now it could be a disaster down the road and what if Finasteride stops working for me then I’m screwed.
So maybe you can get micropigmentation and shave your head, that’s a really good solution in my opinion, I had a ht when i was 27 (almost 5 years ago) and i will go for another one cause i still have hair, but if not, i would go for micro pigmentation for sure, a really good one.
I’m not aware of long term studies that have been done woofy. But it sounds like things are still going okay for you and I recommend not to worry, it just doesn’t help one way or the other. You always do the potential to discuss your options with your doctor like you said.
and thishttps://www.instagram.com/p/COMPTOtDFRW/
As someone who does research in the area of soft materials and drug delivery, and as a balding 25 yr old, this is extremely exciting work. This is, by far, the most plausible and elegant solution to hair loss I have seen on this site. CosmeRNA WORKS. They actually demonstrated it on HUMANS and not mice with 83% efficacy of finasteride without any of the side effects. I believe as drug delivery vehicles improve further, it is very likely that they can suppress the expression of the androgen receptor (which attaches to DHT and releases hair growth inhibitory compounds) almost completely. This then means that there will be no hormonal changes in your body (no ED, loss of libido, brain fog etc.) and no side effects, except maybe some itching due to the physical act of injecting it in your scalp. Again, this is very exciting, very real and the science is solid. The only thing that remains I believe is actually getting all the government approvals and mass producing it for consumption. These are the only reasons why this would maybe take ~3-5 yrs for it to be easily accessible.
That’s all cute but we have learned time and time again that androgen activity at the hair follicle is one downstream play in a larger cascade of events leading to hair miniaturization and death
It will be nice to prolong the inevitable with this OTC but I won’t hold my breath for efficacy
Are you a medical doctor Yosan?
What is exicure doing with 25 million dollar, i am really curious. Their delivery tech is very advanced .
Performing research and development. Most likely in human follicles in a dish and mouse studies.
Some more insight into CosmeRNA: it appears that it may be difficult to be designated as a cosmeceutical but somehow the FDA seems more lenient than the Korean ministry, see the third to last paragraph.https://www.edaily.co.kr/news/read?newsId=01082406632194440&mediaCodeNo=257
This news article is before the Jp morgan conference. Does this change anything? What about the trials they did, is it not enough for safety data?
Thanks to Mathis for the updated news tip
Thats good news to see this progress. But actually its disappointing the results only show 3 to 4 percent imrovement after 24 weeks. I mean what!?
@John Doe: even with zero improvement, maintenance without side effects sounds bad to you? Let me remind you that we still don’t have such a drug in our arsenal
If it was true (and it must be verified, I’ll give you that) it could save a lot of people from baldness if started in time
Follicle Thought,
2 questions:
1. Will I be able to buy this in the US?
2. Do you think this treatment + finasteride can potentially have a synergistic effect, similar to Ru58841 and finasteride?
Mr. Burns, you will be able to buy it in the US when it is approved as a cosmetic in the US. I’m not sure at this time if there will be online ordering options from Europe. This treatment surely has potential to create a synergistic effect with finasteride because of a different mechanism of action. One inhibits 5 alpha reductase, one inhibits androgen receptors.
Hi FT,
Do you think Turn will start their clinical trial this year as said in your interview?
Shayak, thanks for the q. If I had to guess, I would say no it seems more likely that trials start in 2023, perhaps around Q3. Just my guess.
Amazing! I don’t even need 4%. I’ll be happy with stabilization and a hair transplant tbh. I’m in Germany too, so I’m excited to see if this works!
@FT Good morning
Will this be a topical? Is it proven that there is no side effects?
And are you hyped about this one admin? Thkx
Hi gipsy, this is topical. It’s not proven that there are no side effects. There were no serious side effects reported in the trials, but we’ll need to see how the product fairs in the open market to get a better idea. I am happy about this product for sure, that’s why I wrote the article I wouldn’t say hyped, but I think it could be a good option for people who want to add to their regimens or start with a cosmeceutical for maintenance.
In my opinion ,there isn’t any different between before and after using it?
Who knows which (minoxidl or it) better is?
Do others feel the same as Shery?
No. I feel people keep forgetting the importance of maintenance with these treatments.
If they only get a increase of 4% that’s not taking into account how much they could have lost.
And if it’s a different mechanism to existing treatments then it’ll likely just stack.
I feel like many people are not going to be satisfied until they see someone who’s completely bald get back all of their hair. But maintenance and small increase is great for people early into hairloss.
Very thoughtful comment, skyecheeseburger.
@skyecheeseburger
You are completely right,but I think now ,there is minoxidl for maintenancing and small hair falling .what is different between them?I think minoxidl is acting better at growing new hair.isnt it?
Shery
– minoxidil is more for regrowing than maintenancing
– you have to apply minoxidil 14 times a week against 1 time a week for SAMiRNA
– minoxidil has lots of SE, SAMiRNA is meant not to have SE
– minoxidil is something you have to apply until you dies, we still don’t know whether its the case of SAMiRNA
explain to me what do you want more??? minoxidil is sh**
@gipsy
I really appreciate your explanation.
Regrowing is my challenge.both you say right.minoxidl isn’t suitable.
What do u mean about SE?
what’s that?
Which method do u hope would be available sooner?
Sorry I take your time.☘️
Hi everyone! Check out this hair system before and after.https://youtu.be/zpQjfHvFXVI
Why so much excitement over this? 160 comments…
I tried so hard to look at the photos and see the improvement but honestly I can’t. Literally nothing.
Glass half empty: they didn’t gain any hair
Glass half full: they didn’t lose any hair
This drug is for maintenance not regrowth. Another line of defense along with Fin, Minoxidil, micro needling, ketoconazole shampoo, and hair transplants. I ain’t going down without a fight.
#BringMeTheStack
These results are…. Wait for it…. Ridiculous.
It’s 2022 people we should be getting treatment that goes from NW7 to NW1.
Not i have 1 extra hair after 3 months
Max, let us know if you find a place to file a complaint and receive compensation based on the fact that we “should” be getting better treatments. We’d all like better, but it is what it is.
CosmeRNA packaging looks like a cologne you would find at a mall lol. Sorry FT i couldn’t resist
Ha, I don’t mind the humor woofy and I know what you mean. I think the packaging is a Korean thing. As long as the molecules inside do the job they’re expected to, I’m happy.
你好管理员,
Any new article coming up this month?
Shayak yes there should be even if another siRNAgen article. By the way, did you see the recent Dermaliq article?
@admin , yes i have read it. Do you think
PGE2 is a good target? 15 million is a decent amount of money.
I think it could be an alternative to minoxidil type results. The more treatments, the merrier. So to speak. The hair growth effects of latanoprost/bimatoprost are pretty well known and understood. They have a mild/moderate effect.
Hey FT! Do you think it is possible that this treatment will stop any further hair loss? And if so, wouldn’t a hair growth stimulant (like minoxidil) combined with this product be far more effective than on its own?
I think it’s unlikely that this product would stop further hair loss, perhaps more likely to slow it down. But, yes, I do agree that combining this with a hair growth stimulant like minoxidil could produce some nice synergistic results.
Currently I am using alfatradiol mixed with stemoxydine as my evening topical (cannot tolerate minox). Wonder if I should exchange that with cosmeRNA. Anyone has any insightful thoughts about this? Thanks!
https://www.agelessrx.com/powers-hair-solution
Hi has anyone tried this or know if it is worth trying? Thanks
don’t spend the money in this…….
Andy—decent ingredients. Should definitely help a bit.
Is that dnovo interview coming out FT?
YoYo, I know it was planned to potentially release this week, but I am hoping to couple it with another piece of “average” news and have been looking for something like that. Thanks for your patience. It will likely be months before dNovo announces any further progress in the real world.
I understand thank you! Hopefully we get some news from Dnovo this year!
https://news.mtn.co.kr/news-detail/2022031710212379033Han Bio….
YoYo,
Cool article. I really want one of these cell therapies to enter a clinical trial to see what they’re really capable of. There are some bold claims being made. FT, do you think something like HanBio could truly be a cure like the CEO claims?
Thanks for sharing YoYo.
C Bot, no I don’t think their injections will be a true cure for hair loss. In the event the treatment works, I would expect some noteworthy regrowth, but not unlimited.
Hi FT,
Do you believe in the hairclone theory that after repeated injection of DHT resistant DP cells the native hair will slowly start acting like the hairs from the donor area. Their are some papers which suggests that healthy hair signals the adjacent dormant hair to grow , if this is true then this DP cells would a significant achievement, am i right?
Unfortunately, I have to offer a diplomatic answer Shayak – I’m just not sure. I think it’s an idealistic idea that repeat injections will convert hairs into DHT resistant hairs. Sounds theoretically possible, I think maybe the more likely outcome would be (if it works in general) that hairs will become a bit more resilient, but not fully resistant to DHT.
与汉生物、Epibiotech hairclone进入trials very soon, we would have an answer sooner rather than later.
FT and everyone this one is good.https://www.instagram.com/p/CbS-fIyqnvY/
If anyone here has had a hair transplant from hell or simply want your hair back and you have no hope anymore, this is an option for you! Don’t give up!
Woofi97–looks good brother, but I guess I would say that that one is too loose. If I’d go for a Hair system, I would go for the glue option one.
Yeah definitely glue it down.
Should have a new brief article by the end of the day or tomorrow.
There is any new about Triple Hair, Follica or CB??
Thanks in advance!
CB? As in Breezula? I had the update about the website a few days ago..
No news about any of those companies though.
Did they launch their website even though they don’t say anything about the release? Could it be appropriate to contact them? Magai have news ….
https://www.cosmerna.co/
I’m waiting on news from them Luca, thank you.
Any news about release day?
Remi, within a few months I will have an update. The release may be around the end of this year or early 2023 so no worries, you will be informed beforehand.
Any updates?
Not yet Darren, will have one by year’s end.
any updates about cosmerna will they hit the market this year?
marmot, since this article was updated I communicated with June Park. My convo with June led me to believe that early 2023 is a more likely launch time for Cosmerna, than late 2022. The release is planned in EU.
did they get a partner to take it to market? what did she say. this seems to be the most promising treatment being released anytime soon, if it’s released.
I’m not sure johnny, they will be able to launch it themselves if they need to.